Thursday, June 30, 2011

Paper Published: High Resolution Intracranial Wall Imaging

Imaging of the normally-thin artery wall remains a major challenge in MRI. Usually we must sacrifice axial slice thickness to achieve high in-plane spatial resolution, under the assumption that geometry and thickness changes through the ~2-mm-thick slices are negligible.  As we recently demonstrated, however, such thick slice acquisitions may be prone to appreciable artifacts if the slices cannot be perfectly aligned with the vessel.

In the latest issue of JMRI, my colleagues at Johns Hopkins and I report on an approach to achieving isotropic spatial resolutions of 0.4 - 0.5 mm with black blood MRI. Not only does this allow us to resolve Italy (see above); it also allows us to resolve smaller changes or differences in wall thickness while avoiding the abovementioned obliqueness artifacts.

Saturday, June 18, 2011

Nerd Alert

Computational modeling of cerebral aneurysms in popular culture!  -- well, popular nerd culture anyway:  Thanks to BSL alumna Keri Moyle for pointing me to this.

Friday, June 3, 2011

Welcome to Jonathan Mynard

I've been a bit distracted lately, so was remiss in not announcing the addition of Jonathan Mynard from the University of Melbourne.  Jonathan is a NHMRC postdoctoral fellow, who will be investigating the role of imaging and full- and reduced-order models for studying congenital cardiovascular disease.

Editorial in AJNR

Earlier this year Juan Cebral's group published an interesting paper suggested that rare cases of aneurysm rupture following treatment by flow diverters might be due to treatment-induced pressure increases.  Barry Lieber and colleagues subsequently questioned these CFD-based results, which brought a strong response from Cebral and colleagues.  I was then asked by AJNR's Charlie Strother to help explain the controversy for the AJNR readership.

Who is right?  This remains to be seen, but I see it as a terrific opportunity for our community to demonstrate the clinical value (or lack thereof) of image-based CFD.